Mainframe subnet 25
Mainframe positions Subnet 25 as a decentralized science network. Official GitHub sources describe scientific compute for pharmaceutical companies, researchers, and academics, with focus areas such as molecular dynamics and protein-ligand docking. Mainframe is one of the clearest DeSci-oriented Bittensor subnets, connecting distributed compute incentives to research workloads.
About Mainframe subnet 25
Mainframe is Macrocosmos' decentralized science subnet for computational biology and scientific compute.
Scientific simulations can be expensive and compute-constrained, limiting access for researchers and drug-discovery teams.
DeSci researchers, computational biologists, pharma teams, molecular simulation developers, miners, and validators.
Team and ownership
Mainframe is operated within Macrocosmos, led by company co-founders Will Squires and Steffen Cruz.
- Will Squires, CEO & Co-Founder, Macrocosmos: Co-founder and CEO of Macrocosmos, with prior OpenTensor Foundation involvement noted in third-party interviews.
- Steffen Cruz, CTO & Co-Founder, Macrocosmos: Former Opentensor Foundation CTO and Macrocosmos co-founder.
Public partnerships
- Rowan Scientific: Rowan announced a partnership with Macrocosmos around next-generation neural network potential work and cited Mainframe/Subnet 25 as the decentralized science compute layer.
Key pages:
learn about Bittensor,
Bittensor glossary,
Bittensor FAQ,
Bittensor subnet screener,
portfolio tracker,
subnet baskets,
Neuralteq validator,
and fees.